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Thus, ERCC1 expression (be it measured at the mRNA or protein level) has been negatively correlated with survival and responsiveness to cisplatin based regimens in several human neoplasms including bladder (Bellmunt et al., 2007), colorectal (Shirota et al., 2001), gastric (Metzger et al., 1998), esophageal (Kim et al., 2008), head and neck (Handra Luca et al., 2007; Jun et al., 2008) and ovarian cancers (Dabholkar et al., 1992), as well as non small cell lung cancer (NSCLC) (Olaussen et al., 2006). ERCC1 also participates in interstand crosslink repair (ICR), and ICR proficiency appears to be reduced and au.
IMM, a Boulder, Co. Based digital media and marketing agency with 100 staffers, has neither massive scale nor the size typically associated with arbitrage a practice in which the agency takes on the risk of buying media for clients before getting paid by clients.
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